Abstract submission guidelines

On behalf of the Organizing and Program Committees, it is with great pleasure that we announce our 4th Trisomy 21 Research Society (T21RS) International Conference, to be held from June 9-12, 2022, in Long Beach, California.  Building on the success of the recent 2021 Virtual Meeting, the T21RS meeting in 2022 will be in person. We hope to see you there!

The T21RS meetings are devoted to advancing both basic and clinical science in Down syndrome and related areas. The goals of the meeting are to 1) provide a venue for presentation of exciting and innovative research on Down syndrome 2) to engage new researchers to the field and 3) to promote collaboration.

Thus, the Scientific Program Committee is requesting abstracts representing research in basic, clinical, and translational research in Down syndrome, ranging from molecular biology to human research, and especially topics that bridge scientific disciplines. We welcome abstracts from multiple disciplines, including, but not limited to, Down syndrome related disorders, mechanisms underlying developmental challenges, genomics, neuroscience, pharmacological research, new technologies, or sociological aspects (see Themes below).

Key Dates:

Call for abstracts open: March 10, 2022
Deadline for submissions: April 15, 2022
Late-Breaking Abstracts: 21 April - 01 May

This call will also ask abstract submitters to select categories of participation in our meeting, which include 2 broad categories (senior and junior investigator opportunities):

  1. Senior Investigator
    1. Poster abstract only
    2. Poster abstract and consideration for selection in a nanosymposium (see information below – note these will be limited)
  2. Junior Investigator (researchers within 5 years of a completing an MD/PhD) poster abstracts will be:
    1. automatically entered into a poster judging contest with a cash reward
    2. may be selected for a data blitz talk
    3. can be selected for a travel award upon request
    4. can be selected for a childcare award upon request

We appreciate you indicating your interest in one or several of these opportunities (will be indicated as checkboxes on the submission platform).  We will make every effort to accommodate requests.

Requirements for abstract submission

General Information

Authors may submit one abstract as presenting author (although an author can co-author multiple abstracts but not as presenting author).  Abstracts must be in topics related to the theme of the conference, should be original and unpublished and at least one author should be a member of T21RS.

Submission format

Submission Portal: The abstract can be sent through the online platform. Please click on the button below.
We recommend that you prepare your abstract in a text document and then paste it in the corresponding place at the time of submission.
Language: English

Abstract Structure

Authorship there is no limitation on authors but the presenting author must be identified and is allowed to submit only one abstract.
All authors must agree with the content of the abstract.
The presenting author, at minimum, is required to register for and attend the meeting.

Title should not exceed 50 words.
The title of the work must be related to the abstract.

Body of the abstract The abstract must have a minimum of 150 and a maximum of 300 words Please check the number of characters before sending. Before sending, make sure that all the information you want is contained in the summary.

The abstract should be presented with subheadings that include introduction, methods, results, conclusions and funding support. Guidance is below:

Introduction: “What is known about the subject and what is missing?”
In one or two sentences.

Methods: “How was the study conducted?”
Briefly describe: the type of study, context, population and sample, dependent / independent variables, instruments used, data analysis should be according to the type of the variable used / method, etc. Please use the Arrive guidelines in reporting research methods involving the use of animals (see https://www.t21rs.org/preclinical-committee/)

Results: “What was the outcome?”
Describe the major outcomes of the study.

Conclusions: “What is the “take home message” from the work presented?”
The conclusions must be supported by the results.

Funding support: Identify the source of financial support for the study if present.

Information for Nanosymposia

Poster presenters with related topics have the opportunity form a Nanosymposium, which will be a short 30-min session, with a maximum of three speakers.

If you are interested in organizing a Nanosymposium, please identify in your application the one or two accompanying poster titles and presenting authors that should be included. Those posters will also have neighboring slots in the poster area.

Information for Junior Investigator Data Blitz Presentations

 A data blitz is a series of 7-minute talks with 3 min discussion and are intended to a fast paced, dynamic overview of many areas of research by junior investigators presented at the poster sessions. The scientific program committee will select abstracts based on quality and to ensure diversity and invite authors to present.

Information for Junior Investigator Poster Competition

During the first two days of the conference, posters and Data Blitz presentations will be judged by senior members of T21RS based on the highest scientific excellence, presented in the most effective way.

During the Gala Dinner, on June 11th, 2022, we will announce the 3 poster winners, one from each category (undergraduate, graduate, and postdoctoral). In addition to a cash prize, free membership in T21RS for one year, free registration for the next in person meeting will be provided and each of the winners will be featured on the T21Rs website.



Theme 1. Genomic and epigenetic mechanisms: Genetics, genomics, epigenetics, other -omics (transcriptome, metabolome, proteome, exposome, single-cell etc.), 3D genome organisation, multiomic modelling

Theme 2. Molecular and Cellular Mechanisms: Neurobiological, immunological, metabolism, synaptic mechanisms, plasticity, neuronal networks, etc

Theme 3. Experimental models: Animal models, cellular models, organoids, stem cells and reprogramming, etc.

Theme 4. Cognition and Behavior: Clinical and preclinical studies on cognition and behaviour, intellectual disability, language, behavior, emotion, executive functions, sex-specific differences, neuropsychological evaluation tools

Theme 5. Neurodegeneration and Ageing: Alzheimer disease in Down syndrome, neuropathology, immunosenescence, cognitive decline, etc.

Theme 6. Neurodevelopment: Neuropathology, neurogenesis, cell proliferation and differentiation, synaptogenesis, nervous system patterning, etc.

Theme 7. Co-occurring Illnesses: Cancer/ leukemia, psychiatric disorders, metabolic disorders, sensory disorders, cardiovascular diseases, etc.

Theme 8. Therapeutic intervention: Pharmacological/non-pharmacological interventions, neurotherapy, preclinical drug development, experimental therapeutics, clinical trials

Theme 9. Diagnosis and Evaluation: Biomarkers, neuroimaging, outcome measures

Theme 10. Other

Thank you on behalf of the Scientific Program Committee,